TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntramuscularSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 720 mg/kg/2Y-ITOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin\'s disease Tumorigenic - tumors at site of applicationREFERENCE : NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year: PH43-64-886

TYPE OF TEST : TD - Toxic dose (other than lowest)ROUTE OF EXPOSURE : IntramuscularSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 900 mg/kg/2Y-ITOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Musculoskeletal - tumors Tumorigenic - tumors at site of applicationREFERENCE : PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958- Volume(issue)/page/year: 14,68,1971

TYPE OF TEST : TD - Toxic dose (other than lowest)ROUTE OF EXPOSURE : IntramuscularSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 430 mg/kg/81W-ITOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin\'s disease Tumorigenic - tumors at site of applicationREFERENCE : NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Franc

TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : OralSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 26 gm/kg/2Y-ITOXIC EFFECTS : Tumorigenic - equivo

TYPE OF TEST : TD - Toxic

TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : IntraperitonealSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 25 mg/kgTOXIC EFFECTS : Details of toxic effects not reported other than lethal dose valueREFERENCE : NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year: PH43-64-886

TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : IntraperitonealSPECIES OBSERVED : Rodent - mouseDOSE/DURATION : 60 mg/kgTOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)REFERENCE : NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year: PH43-64-886

TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Rodent - mouseDOSE/DURATION : 180 mg/kgTOXIC EFFECTS : Details of toxic effects not reported other than lethal dose valueREFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00774

TYPE OF TEST : Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimuriumDOSE/DURATION : 100 ug/plateREFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983

TYPE OF TEST : Morphological transformationTEST SYSTEM : Rodent - rat EmbryoDOSE/DURATION : 2960 ug/LREFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST : Morphological transformationTEST SYSTEM : Rodent - mouse FibroblastDOSE/DURATION : 800 ug/LREFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST : Morphological transformationTEST SYSTEM : Rodent - hamster EmbryoDOSE/DURATION : 100 ug/LREFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntraperitonealSPECIES OBSERVED : Rodent - mouseDOSE : 60 mg/kgSEX/DURATION : female 10 day(s) after conceptionTOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 33,171,1984

TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntraperitonealSPECIES OBSERVED : Rodent - mouseDOSE : 30 mg/kgSEX/DURATION : female 10 day(s) after conceptionTOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 33,171,1984